A Novel Model of Acute Hepatic Failure in Dogs With Implications for Transplantation Research.

I N THE LAST few years, liver transplantation has been indicated as therapy for patients with acute hepatic failure.! Since liver transplantation represents the last therapeutic option for this entity, it is extremely important to define the timing for the operation based on the evolution of the clinical parameters of the disease. On the basis of studies conducted on an acetaminophen-induced model of hepatotoxicity in large animals that we previously described/ we have defined a new model for acute hepatic failure that lends itself to this type of study.